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In Medical Journals/ Research artticles 2
Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis
Introduction: Since 2002, the WHO has recommended either nevirapine (NVP) or efavirenz (EFV) as part of first-line antiretroviral therapy. These two drugs are known to have differing toxicity profiles, but the risk of these toxicities overall is not well established.
Strategies for reducing treatment default in drug-resistant tuberculosis: systematic review and meta-analysis
BACKGROUND: Scaling up treatment for multi-drug-resistant tuberculosis is a global health priority. However, current treatment regimens are long and associated with side effects, and default rates are consequently high. This systematic review aimed to identify strategies for reducing treatment default.
Last updated 23 February 2013
MSF submission for the inclusion of peginterferon alfa-2a and -2b in the WHO Essential Medicines List
Summary statement of the proposal for inclusion Inclusion of the injectable formulation of peginterferon alfa-2a and -2b is proposed for the treatment of hepatitis C among adults. The principal reasons for requesting this inclusion are as follows: 1. There is significant burden of hepatitis C disease among adults living in resource-limited settings.
Last updated 8 January 2013
After a major upsurge in the 1990s, HAT is now under control in most endemic regions. To prevent resurgence from re-occurring, which we know will happen if control efforts are relaxed, the continuation of control activities is crucial. In the DRC the knowledge, expertise and capacity are in place; continued funding of the national HAT control programme would allow for these to be utilized and the epidemiological situation to be kept under control.
Last updated 17 December 2012
Introduction: Leishmaniasis is a parasitic disease transmitted by phlebotomine sandflies. Between 700,000 and 1.2 million cases of cutaneous leishmaniasis and between 200,000 and 400,000 cases of visceral leishmaniasis (VL), which is fatal if left untreated, occur annually worldwide. Liposomal amphotericin B (LAMB), alone or in combination with other drugs, has been extensively studied as VL treatment, but data on routine field use are limited, and several challenges to patients’ access to this life-saving drug remain.
Last updated 17 December 2012
Public health advocacy for the Berlin Declaration on Tuberculosis in the Former Soviet Union: The view of MSF
Last updated 13 December 2012
Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis
Background: Current anti-tuberculosis therapeutics are not sufficiently effective against drug-resistant tuberculosis (DR-TB), and there is a need for new drugs and therapeutic approaches. It has been proposed that repurposing clofazimine for DR-TB treatment might be one way to increase therapeutic options.
Last updated 12 October 2012
Challenges and opportunities for the implementation of virological testing in resource-limited settings
Last updated 10 October 2012
Last updated 27 September 2012
Last updated 30 August 2012