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The patent pool could deliver much needed new combination therapies

There aren’t enough of these ‘fixed-dose combination’ drugs (FDCs) at the moment for either adults or children. A patent pool could change that and deliver lots of new FDCs, vastly increasing the treatment options for people with HIV in the developing world.

Here is a table of FDCs that it’s hoped the patent pool could deliver:

 Fixed-dose combination therapies for Adults

Double FDCs

TDF/FTC
3TC/AZT
ABC/3TC
LPV/r
ATV/r
FPV/r
DVR/r

Triple FDCs

TDF/FTC/EFV
TDF/3TC/EFV
TDF/3TC/NVP
TDF/FTC/NVP
AZT/3TC/NVP
3TC/AZT/ABC
d4T/3TC/NVP

Quadruple FDCs

LPV/r/TDF/3TC
ATV/r/TDF/3TC
ATV/r/3TC/ABC

Fixed-dose combinations in co-blister*

ddI+LPV/r/ABC
ddI+LPV/r/3TC
ddI+ATV/r/3TC
TDF/3TC+NVP

 *means the two pills are presented in one blister pack

Fixed-dose combination therapies for Children

Double FDCs

AZT/3TC
d4T/3TC
ABC/3TC
EFV/FTC
LPV/r
ATV/r
FPV/r
DVR/r
TPV/r

Triple FDCs

AZT/3TC/NVP
 d4T/3TC/NVP
ABC/AZT/NVP
 AZT/3TC/ABC

Fixed-dose combinations in co-blister*

ddI+ABC/LPV/r
ddI+AZT/LPV/r

 *means the two pills are presented in one blister pack

Please refer to MSF’s ‘Untangling the Web’ to get the full names of the drugs referred to in the table.

Click here to download Untangling the Web .