PUSH, PULL, POOL: Accelerating Innovation and Access to Medicines for Tuberculosis
Proposal for a CEWG Demonstration Project by Médecins Sans Frontières (MSF)
The World Health Organization (WHO), as part of its broader efforts to address health R&D gaps for the poor, is conducting a process whereby member states will support "health R&D demonstration projects" aimed at developing health technologies (medicines, diagnostics, medical devices, vaccines, etc.) for diseases that disproportionately affect developing countries and for which identified R&D gaps remain unaddressed due to market failures.
MSF’s proposal to accelerate the development of new treatment regimens for tuberculosis (TB) through new models of innovation, Accelerating Innovation and Access to Medicines for Tuberculosis through Open Collaboration: A Push, Pull, Pool Approach (3P Project), is one of 22 proposals selected by WHO regional offices to be considered by a group of experts at the WHO’s Global Technical Consultative meeting in December 2013. The experts will develop a shortlist of projects to be taken to the WHO Executive Board and World Health Assembly in January and May 2014, respectively.
More effective, shorter treatment regimens for TB and MDR-TB are needed.
The '3P Project'
The aim of the ‘3P Project’ is to rapidly deliver affordable, effective new regimens for tuberculosis (TB). It will do this through creating an open collaborative framework for conducting drug development and through novel approaches to financing and coordinating research and development (R&D). The 3P Project implements three mechanisms to facilitate the necessary and appropriate R&D for TB drug regimens:
- › push funding to finance R&D activities upfront (i.e. through grants)
- › pull funding to incentivise R&D activities through the promise of financial rewards on the achievement of certain R&D objectives (i.e. through milestone prizes)
- › pooling of intellectual property to ensure open collaborative research and to ensure fair licensing for competitive production of the final products